Inflammatory process in almost all cases accompanies rheumatic pathology, significantly reducing the quality of life of the patient. That is why one of the leading areas of therapy for joint diseases is anti-inflammatory treatment. Several groups of drugs have this effect for otc pain relief: non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids for systemic and topical application. For severe pain relief people mainly use Tramadol, Morphine, Ultracet medicine, Ultram with prescription of doctor. Aleve is one of NSAIDs, used to treat inflammatory and degenerative diseases of the musculoskeletal system.
Is Aleve an anti inflammatory drug?
Aleve (Naproxen) has analgesic, anti-inflammatory and antipyretic properties. Also, the pain syndrome is weakened (including when the ligaments of the knee joint are ruptured). Is Aleve over the counter? It is over the counter pain reliever. The mechanism of action of the medicament consists in the pharmacological inhibition of prostaglandin synthetase and fatty arachidonic acid, after which the synthesis of lipid prostaglandins in the body is suppressed. It does not have carcinogenic properties, reduces blood clotting.
Pharmacokinetics of Aleve
The absorption of the tissues of the medicine is fast and complete. Bioavailability of the medication reaches 95%. The separation period is from 12 to 17 hours. The connection with proteins reaches 98%. Isolation occurs mainly through the kidneys (about 94% of the medicine is excreted in the urine), about 3% – with feces, about 2.5% comes out with bile. Binding to plasma proteins reaches 99%. The steady-state concentration of the substance in the blood is 4 to 5 days. The analgesic effect is manifested after 1-2 hours with duration of action of 3 to 7 hours. The anti-inflammatory effect is achieved after 2 weeks. With kidney failure, accumulation in the kidneys of the active substance can be observed. How many Aleve can you take in a day? The dosage of the drug in the form of tablets depends on the disease.
Can pregnant women take Aleve?
Studies of drugs in pregnant women have not been carried out, however, when testing animals, teratogenic effects have not been demonstrated. Therefore, it is impossible to predict the exact effect on a person. Although in comparison with opioid analgesic as Ultracet tablet which is forbidden during pregnancy, Aleve dosage can be used only in those cases when the symptoms and disease completely coincide with the indications, and the benefits of treatment are many times higher than the risk for the fetus.
In case of an overdose, the following occurs as drowsiness, feeling dizzy, nausea, vomiting, discomfort in the abdomen, lethargy, peripheral edema, bronchospasm, diarrhea, angioedema, cystitis, itching, leukopenia, internal bleeding in the stomach. In rare cases prescription Aleve leads to hypertension, jaundice, leukopenia, respiratory depression, acute renal failure and coma. In case of an overdose, it is necessary to stop the drug immediately.
Adviсes of patients
Leaving feedback, many patients indicate that the remedy perfectly removes pain and removes inflammation. Some also emphasize its high effectiveness, compared with other preparations that could not fully alleviate the pain syndrome when the ligaments of the knee joint were ruptured. However, patients over 60 years should use the minimum daily dose. The most important thing is to follow the instructions clearly, do not exceed the indicated dose and duration of therapy. In case of violation of these rules, it is necessary to check the kidney and liver function of your doctor.
Can dogs take Aleve?
Some of the most common available painkillers fall into the group of non-steroidal anti-inflammatory drugs (NSAIDs). This includes such common examples as Ibuprofen and Aleve. Their action is based on the inhibitory enzyme cyclooxygenase, which is responsible for the production of prostaglandins, which promote the development of inflammation, fever and pain. But prostaglandins also play many other roles in the body, including participating in the maintenance of blood flow in the kidneys, the production of mucus, which protects the internal walls of the gastrointestinal tract from gastric acid, normal blood clotting. When these functions are weakened, dogs can have vomiting and diarrhea (often bloody), lose appetite, break blood clotting, refuse kidneys or liver or break their function. Animals can even die without proper treatment. When using NSAIDs, problems may occur for the following reasons:
-The owner gives a disproportionately large dose of one or more drugs.
-Some dogs are particularly sensitive to NSAIDs. Dangerous side effects can be developed even with the correct dose of the remedy.
-Simultaneous administration of other drugs (e.g., corticosteroids) and / or the presence of certain health problems (for example, in the gastrointestinal tract, liver or kidneys) can make the use of NSAIDs for dogs more risky.